Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway / 中国实验方剂学杂志

Sepsis is a kind of systemic inflammatroy response syndrome (SIRS) induced by severe infection,operation,and trauma,with high mortality rate,treatment cost,and high consumption of medical resources.It has caused a great burden to the medical industry and even the national economy.Therefore,it is urgent to find effective treatment methods for sepsis.At present,the sepsis has been treated with certain drugs pointing at its pathogenesis,such as antibiotics,glucocorticoids,and vasoactive drugs.,but the therapeutic effect is not ideal,with many side effects,poor prognosis,and high clinical mortality.Based on the overall macro-dialectical thinking mode,and with the unique effect and low side effect,traditional Chinese medicine (TCM) has attracted the attention from researchers and clinicians around the world for treatment of sepsis.In recent years,some traditional Chinese medicine prescriptions,Chinese patent medicines,single Chinese medicines and active ingredients are increasingly used as new drugs to prevent and treat sepsis.Such treatment methods have been widely recognized and have reduced the mortality and inflammatory indexes of patients to a certain extent,playing an important role in the prevention and treatment of sepsis.In this paper,the actions of nuclear factor kappa B (NF-κB) signal pathway in sepsis as well as the advances in research of NF-κB signal pathway-related proteins in Chinese medicine for sepsis were reviewed.

Promotion on systematic quality standard of Shufeng Jiedu Capsule / 中草药

The idea and model of quality research on traditional Chinese medicinal materials and compound Chinese materia medica were established and this method was applied to systematical promoting the quality standard of raw herbal materials and preparation of Shufeng Jiedu Capsule (SJC). The chemical components from Polygoni Cuspidati Rhizoma et Radix, Forsythiae Fructus, Isatidis Radix, Bupleuri Radix, Patriniae cum Radice Herba, Verbenae Herba, Phragmitis Rhizoma, and Glycyrrhizae Radix et Rhizoma were identified and 184 compounds were determined. The fingerprints of the eight medicinal materials were established, 10 compounds were identified as the anti-inflammatory substance of SJC by studying the correlation between chemical components and their anti-inflammation effect. The methods of multi-component determination and fingerprint controlling have been established and the quality standard of SJC has been improved comprehensively.

Advances in studies on Chinese materia medica for treatment of ulcerative colitis based on NF-κB signal pathway / 中草药

Ulcerative colitis (UC) is a chronic and relapsing condition of the intestinal inflammation of unknown etiology and remains one of the most intractable gastrointestinal diseases, impairing quality of life and carrying a high risk of colorectal cancer in patients with UC. Currently, aminosalicylic acid, steroid hormone, and immunosuppressor are the main drugs for treating UC. However, all of them can not cure UC once and for all. In recent years, many scholars attempted to find new drugs in the extracts and active compounds from herbs for the prevention and treatment of UC. The paper summarized the status of nuclear factor kappa B (NF-κB) signal pathway of UC, and those anti-inflammation Chinese materia medica regarded proteins and enzymes of NF-κB pathway as targets.

Overview of extracting technique of compound Chinese materia medica / 中草药

As the key operation step in the production of compound Chinese materia medica (CMM) or the natural products, extracting technique not only directly affects the quality of CMM preparations, medicinal resource utilization, and clinical efficacy, but also relates to the development of Chinese pharmaceutical industry. On the basis of consulting literatures, extracting techniques appearing in recent five years are particularly reviewed in the traditional extracting method, new extracting technique, evaluating indicator, and process variable optimization. Further research application and development prospects of these extracting techniques are also suggested.

Establishment of scientific principles on evaluation system for compound Chinese materia medica extraction and separation / 中草药

Compound composition of several natural products including plants,animals,and minerals.In the different needs of Chinese medicine research and application,different extraction and separation methods have been chosen,however,these technologies lacked of scientific and reasonable evaluation criteria because most of these technologies stem from other disciplines,which is the main reason for limited application of the method in Chinese medicine.So the key scientific issue is to establish the quality evaluation system of extraction and separation technology in line with the modern medicine.This article aims to establish the scientific principles of evaluation system for extraction and isolation of Chinese herbal compound.